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Ohno's law
Ohno's law was proposed by a Japanese biologist Susumu Ohno, saying that the gene content of the mammalian species has been conserved over species not only in the DNA content but also in the genes themselves. That is, nearly all mammalian species have conserved the X chromosome from their primodial X chromosome of a common ancestor.〔Ohno S (1967). ''Sex Chromosomes and sex-linked genes.'' Berlin:Springer-Verlag.〕 == Evidence == As a cytological evidence, in first, mammalian X chromosomes in various species, including human and mouse, have nearly the same size, with the content of about 5% of the genome. Second, for individual gene loci, a number of X-linked genes are common through mammalian species. Examples are found in glucose-6-phosphate dehydrogenase (G6PD), a gene for polypeptide of antihemophilic globulin (AHG or Factor VIII) in hemophilia A and B, and plasma thromboplastin component gene (PTC or Factor IX). Moreover, no instances were found where an X-linked gene in one species was located on an autosome in the other species.〔
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